Why TheranosticTrials.org?

The leading global platform for radiopharmaceutical & molecular imaging clinical trials

Global Reach

We are uniquely positioned at the heart of Theranostics.

Increasing Awareness

We're dedicated to increasing awareness about Theranostics and it's potential.

Fostering Engagement

We encourage active participation in the Theranostics community.

Building Connections

We connect physicians, clinics, and patients with Theranostic opportunities.

Comprehensive Resources

Access a complete list of cancer Theranostic Trials and educational materials.

Advancing the Field

We collaborate with key opinion leaders to push Theranostics forward.

Our Ultimate Goal

Provide more hope to cancer patients everywhere!


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Theranostic Research Report

Source: Oppenheimer & Co. Research

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Isotopes

View details about the isotopes used in the trials listed on our site!

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LUTETIUM-177
Radioisotope: Lu-177
Theranostic Role: Therapeutic Agent & SPECT Imaging
T1/2 (Half-Life): 6.7 Days
Decay Mode: BETA, GAMMA
Energy: Eβeta max 497 keV, Gamma 113-208 keV
Range: In Tissue: 0.25-2mm
Decay Daughters: Hf177
Status: FDA Approvals: PLUVICTO® (2022), LUTATHERA® (2017)
SAMARIUM-153
Radioisotope: Sm153
Theranostic Role: Therapeutic
T1/2 (Half-Life): 1.9 Days
Decay Mode: BETA, GAMMA
Energy: Beta: Max 808 keV Gamma: 103 keV (28%)
Range: 0.6 mm
Decay Daughters: Eu153 (Stable)
Status: FDA Approval: QUADRAMET® (1997)
TECHNETIUM-99m
Radioisotope: Tc-99m
Theranostic Role: SPECT Imaging
T1/2 (Half-Life): 6 Hours
Decay Mode: GAMMA
Energy: 140 keV (89.1%)
Range: N/A
Decay Daughters: Tc99
Status: FDA Approval: First in 1980’s

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Distinguished Investigator

A Distinguished Investigator of Theranostics is a level of distinction conferred upon an individual physician who has demonstrated a mastery of conducting novel radioligand therapies and molecular imaging clinical trials.

Jeff Michalski, MD

Dr. Michalski is a prostate cancer specialist, Chair of the Theranostics sub-Committee for NRG, and the Vice Chair of the Department of Radiation Oncology at Washington University Medical School. He serves as the medical director of the Siteman Cancer Center’s Clinical Trial Office and has served as the Principal Investigator for the Radiation Therapy Oncology Group at Washington University. He earned his medical degree from the Medical College of Wisconsin in Milwaukee and completed his internship in internal medicine at Columbia-Presbyterian Medical Center in New York, and residency in radiation oncology at Mallinckrodt Institute of Radiology at Washington University School of Medicine in St. Louis. Dr. Michalski’s research interests include radiation dose escalation in the management of prostate cancer; precision radiation therapy to reduce toxicity in late neuro-cognitive effects in children with medulloblastoma; and assessment of quality of life in survivors of adult and childhood malignancies. He served as the Principal Investigator of the Advanced Technology Consortium (ATC) and coordinated Quality Assurance of radiation therapy trials in the cooperative group programs. As the leader of the RTOG ATIC, he established guidelines for participation of emerging technologies such as Intensity Modulated Radiation Therapy (IMRT), Stereotactic Body Radiation Therapy (SBRT) and Proton Beam Radiation Therapy (PBRT). He was instrumental in coordinating trials that involved advanced imaging, such as RTOG 0522 and stereotactic body radiation therapy, such as RTOG 0236. As the PI of the ATC, he coordinates quality assurance of clinical trials using PBRT for Massachusetts General Hospital, and MD Anderson Cancer Center. He served as Co-Principal Investigator on a joint contract with the Veteran's Administration Medical Centers and ASTRO to develop a system to provide continuous feedback on the progress, quality and safety of veterans' cancer therapy.

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RLT Components

RADIOLIGAND THERAPY (RLT) is a highly effective approach to very accurately locating cancer cells and effectively killing those same cells by delivery various radioisotopes to a specific target that is located on a type of cancer. Some of the Radioisotopes are diagnostic for locating cancers & some therapeutic to treat the cancers.

There are several Components to a RLT that are simply demonstrated in the truck diagram including:

  1. Cancer Targets
  2. Ligand (demonstrated as the Truck GPS set to find a specific Target)
  3. Diagnostic Radioisotopes (demonstrated as light bulbs that light the cancer Targets on a PET scan)
  4. Therapeutic Radioisotopes (demonstrated as bombs that kill cancer cells that express the target with either Alpha or Beta radiation)
  5. Linker (demonstrated as the hitch keeping the Radioisotope attached to the Ligand)
  6. Chelator (demonstrated as the Trailers which keeps the Radioisotope on Target).

To learn more about the specific components being studied today on clinical trials around the world check out the RLT COMPONENTSTab.

View RLT Components

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