Study Title

Clinical Evaluation of Lutetium-177 Labeled BQ7876 for Targeting of Prostate-Specific Membrane Antigen

Study Details

Description:

The study should evaluate the biological distribution of [177Lu]Lu-BQ7876 in patients with prostate cancer. The objective are: To evaluate the content of [177Lu]Lu-BQ7876 in the blood of patients with prostate cancer at different time points after a single intravenous administration. To assess the distribution of [177Lu]Lu-BQ7876 in normal tissues and tumors at different time points. To evaluate dosimetry of [177Lu]Lu-BQ7876. To study the safety and tolerability of the drug [177Lu]Lu-BQ7876 after a single injection.

Sponsor:

Tomsk National Research Medical Center of the Russian Academy of Sciences

Drug Details

[177Lu]Lu-BQ7876.
Isotope(s):
    LUTETIUM-177
    Radioisotope: Lu-177
    Theranostic Role: Therapeutic Agent & SPECT Imaging
    T1/2 (Half-Life): 6.7 Days
    Decay Mode: BETA, GAMMA
    Energy: Eβeta max 497 keV, Gamma 113-208 keV
    Range: In Tissue: 0.25-2mm
    Decay Daughters: Hf177
    Status: FDA Approvals: PLUVICTO® (2022), LUTATHERA® (2017)
  • LUTETIUM-177
Target(s):
  • PSMA

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