Study Title

bayer

A Phase 1 Open-label, First-in-human, Multi-center Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of 225Ac-PSMA-Trillium in Participants With Advanced Metastatic Castration-resistant Prostate Cancer (mCRPC)

Study Details

Description:

Researchers are looking for a better way to treat men who have metastatic castration-resistant prostate cancer (mCRPC). mCRPC is a cancer of the prostate (male reproductive gland found below the bladder) that has spread to other parts of the body. This type of prostate cancer does not respond to hormone treatment used to lower the level of testosterone, a male sex hormone, to prevent cancer from growing. The study treatment 225Ac-PSMA-Trillium, also called BAY3563254, is under development to treat advanced metastatic castration-resistant prostate cancer. It works by binding to PSMA and giving off radiation that can damage cancer cells and stop them from growing.

Sponsor:

Bayer

Contacts:

Bayer Clinical Trials Contact

clinical-trials-contact@bayer.com

1-888-84 22937

Drug Details

111In-PSMA-Trillium (BAY3632687)
Isotope(s):
    INDIUM-111
    Radioisotope: In-111
    Theranostic Role: SPECT Imaging
    T1/2 (Half-Life): 2.8 Days
    Decay Mode: ELECTRON CAPTURE, GAMMA
    Energy: 173 keV, 247 keV
    Range: N/A
    Decay Daughters: Cd111 (Stable)
    Status: FDA Approvals: ONCOSCINT® (1992), OCTREOSCAN® (1994)
  • INDIUM-111
Target(s):
  • PSMA
Ligand: Small Molecules
225Ac-PSMA-Trillium (BAY3563254)
Isotope(s):
    ACTINIUM-225
    Radioisotope: Ac-225
    Theranostic Role: Therapeutic Agent & SPECT Imaging
    T1/2 (Half-Life): 9.9 Days
    Decay Mode: ALPHA, GAMMA
    Energy: 5.8-8.4 MeV
    Range: 47-85 micrometers
    Decay Daughters: Ra225, Fr221, At217, Bi213, 209, Po213, 209, TL209, 205
    Status: Clinical Trials Only
  • ACTINIUM-225
Target(s):
  • PSMA
Ligand: Small Molecules

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